Pressure Changes in the Cerebro-spinal Fluid following Intravenous Injection of Solu- Tions of Various Concentrations

In an attempt to determine whether, following intravenous injection of hypertonic solutions of sodium chloride, an increased amount of this salt could be detected in the cerebra-spinal fluid, it was noted that within a short time after the intravenous injection, cerebra-spinal fluid could not be obtained when the subarachnoid space was entered. This observation led at once to the attachment of a manometer to the puncture needle for the purpose of making continuous readings of the cerebra-spinal fluid pressure following the intravenous injection of hypertonic solutions of sodium chloride. It was soon found that the pressure of the cerebra-spinal fluid could be altered very rapidly and very definitely by intravenous injections of solutions of various concentrations.